Loop diuretic use has been shown to be associated with an increased fracture risk, but the findings have been inconsistent. The present meta-analysis suggests that loop diuretics show a significant positive association with the overall risk of total fractures and, specifically, hip fractures.

目的:提供步态分析常用的运动平衡分析算法和逻辑,为运动平衡分析提供处理和研究平台。方法:基于c#编程语言,通过MVC设计模式,在总结步态实验常用到的方法、过程和需求基础上完成幵发。结果:实现了集成数据分析、文件批处理和实验工具的三维步态分析辅助系统,该系统包含了用于运动平衡数据分析的步态数据处理模块,针对运动分析大数据的批处理模块以及斯特鲁普测试模块。结论:该系统具有较强的鲁棒性和可扩展性,己在上海交通大学MED-X步态实验室幵展广泛应用并得到好评。

目的 应用最大重心-压力中心倾角法比较青、中、老年人群静态平衡能力差异及特征。方法 使用三维运动捕捉系统及测力台，采集15名青年人(18~40岁)、10名中年人(41~65岁)及12名老年人(>65岁)在睁眼双足站立、闭眼双足站立、睁眼单足站立及闭眼单足站立4种状态下的重心及压力中心数据，计算其在矢、冠状面上的重心-压力中心倾角，以各组平均峰值进行统计 分析。结果 在睁眼双足站立及闭眼单、双足站立3种状态下，不同年龄段人群在矢、冠状面的倾角均无显著性差异(P>0.05)；而在睁眼单足站立时，青、中年组与老年组间，在矢、冠状面的倾角均有显著性差异(P<0.05)。结论 睁眼单足站立下的最大重心-压力中心倾角可以敏感地检测出老年人群的平衡功能衰退，有望为临床静态平衡提供一种新的静态平衡评估指标。

Wear particle-induced osteolysis and subsequent aseptic loosening remains the most common complication that limits the longevity of prostheses. Wear particle-induced osteoclastogenesis is known to be responsible for extensive bone erosion that leads to prosthesis failure. Thus, inhibition of osteoclastic bone resorption may serve as a therapeutic strategy for the treatment of wear particle induced osteolysis. In this study, we demonstrated for the first time that geraniin, an active natural compound derived from Geranium thunbergii, ameliorated particle-induced osteolysis in a Ti particle-induced mouse calvaria model in vivo. We also investigated the mechanism by which geraniin exerts inhibitory effects on osteoclasts. Geraniin inhibited RANKL-induced osteoclastogenesis in a dose-dependent manner, evidenced by reduced osteoclast formation and suppressed osteoclast specific gene expression. Specially, geraniin inhibited actin ring formation and bone resorption in vitro.